John F Cryan Selected Research

Weight Gain

11/2021	Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes.
8/2021	Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent.
3/2020	Metformin and Dipeptidyl Peptidase-4 Inhibitor Differentially Modulate the Intestinal Microbiota and Plasma Metabolome of Metabolically Dysfunctional Mice.
6/2018	A casein hydrolysate increases GLP-1 secretion and reduces food intake.
8/2015	Bovine serum albumin as the dominant form of dietary protein reduces subcutaneous fat mass, plasma leptin and plasma corticosterone in high fat-fed C57/BL6J mice.
2/2015	A natural solution for obesity: bioactives for the prevention and treatment of weight gain. A review.
1/2015	Whey protein isolate decreases murine stomach weight and intestinal length and alters the expression of Wnt signalling-associated genes.
1/2015	Compared to casein, bovine lactoferrin reduces plasma leptin and corticosterone and affects hypothalamic gene expression without altering weight gain or fat mass in high fat diet fed C57/BL6J mice.
1/2014	Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and the gut microbiota in C57BL/6J mice.
12/2013	Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes.

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John F Cryan Research Topics

Disease

25	Obesity 01/2023 - 01/2010
16	Mental Disorders (Mental Disorder) 12/2022 - 06/2003
15	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/2021 - 01/2009
14	Inflammation (Inflammations) 01/2023 - 01/2014
13	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2023 - 02/2013
13	Body Weight (Weight, Body) 01/2023 - 05/2012
12	Weight Gain 11/2021 - 05/2012
11	Hypersensitivity (Allergy) 03/2023 - 06/2010
11	Pain (Aches) 08/2022 - 09/2011
11	Schizophrenia (Dementia Praecox) 01/2022 - 05/2012
9	Anxiety Disorders (Anxiety Disorder) 01/2022 - 06/2006
9	Visceral Pain 01/2022 - 09/2011
7	Brain Diseases (Brain Disorder) 01/2022 - 01/2015
7	Neuroinflammatory Diseases 10/2020 - 01/2015
6	Hypothermia 08/2022 - 11/2003
6	Neoplasms (Cancer) 01/2022 - 01/2010
5	Cognitive Dysfunction 04/2022 - 10/2016
5	Autistic Disorder (Autism) 01/2020 - 04/2015
5	Treatment-Resistant Depressive Disorder 01/2017 - 04/2009
4	Necrosis 01/2022 - 05/2012
4	Insulin Resistance 01/2022 - 06/2012
4	Substance-Related Disorders (Drug Abuse) 01/2021 - 11/2005
4	Mood Disorders (Mood Disorder) 01/2019 - 01/2005
4	Bacterial Infections (Bacterial Infection) 01/2015 - 10/2012
3	Alzheimer Disease (Alzheimer's Disease) 08/2023 - 09/2007
3	Huntington Disease (Huntington's Disease) 02/2023 - 02/2013
3	Neurodevelopmental Disorders 11/2022 - 01/2018
3	Alcoholism (Alcohol Abuse) 01/2021 - 01/2015
3	Hypertension (High Blood Pressure) 10/2020 - 12/2018
3	Hypoxia (Hypoxemia) 09/2020 - 01/2017
3	Infections 10/2019 - 01/2017
3	Seizures (Absence Seizure) 03/2018 - 04/2015
3	Anhedonia 01/2018 - 10/2014
3	Brain Neoplasms (Brain Tumor) 12/2017 - 04/2015
3	Bipolar Disorder (Manic Depressive Psychosis) 12/2016 - 03/2014
3	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 12/2016 - 05/2015
3	Nervous System Diseases (Neurological Disorders) 10/2016 - 10/2014
3	Chronic Pain 08/2014 - 06/2010
2	Depressive Disorder (Melancholia) 11/2023 - 12/2018
2	Dementia (Dementias) 08/2023 - 02/2017
2	Major Depressive Disorder (Major Depressive Disorders) 01/2023 - 03/2014
2	Colitis 01/2022 - 01/2017

Drug/Important Bio-Agent (IBA)

13	Anti-Bacterial Agents (Antibiotics)IBA 01/2023 - 10/2012
12	Tryptophan (L-Tryptophan)FDA Link 08/2023 - 01/2009
11	Proteins (Proteins, Gene)FDA Link 02/2023 - 06/2006
11	CytokinesIBA 08/2022 - 05/2012
10	Biomarkers (Surrogate Marker)IBA 08/2023 - 10/2009
10	LeptinIBA 01/2023 - 07/2010
9	Antidepressive Agents (Antidepressants)IBA 11/2023 - 06/2007
8	GhrelinIBA 01/2023 - 01/2010
7	CorticosteroneIBA 01/2023 - 06/2012
7	PrebioticsIBA 01/2022 - 02/2015
7	Ghrelin ReceptorsIBA 01/2019 - 01/2010
7	gamma-Aminobutyric Acid (GABA)IBA 05/2016 - 01/2005
6	KynurenineIBA 08/2022 - 01/2012
6	Serotonin (5 Hydroxytryptamine)IBA 08/2022 - 01/2012
6	Baclofen FDA LinkGeneric 01/2015 - 09/2004
6	GABA-B ReceptorsIBA 11/2013 - 05/2005
5	Caseins (Casein)FDA Link 11/2021 - 12/2013
5	LigandsIBA 01/2021 - 10/2011
5	Messenger RNA (mRNA)IBA 01/2017 - 12/2009
5	Glutamic Acid (Glutamate)FDA Link 01/2015 - 06/2010
4	Volatile Fatty AcidsIBA 08/2023 - 09/2020
4	Insulin (Novolin)FDA Link 01/2023 - 06/2012
4	Opioid Analgesics (Opioids)IBA 01/2021 - 04/2016
4	Nicotine FDA Link 01/2021 - 01/2015
4	SolutionsIBA 01/2021 - 01/2015
4	Antipsychotic Agents (Antipsychotics)IBA 01/2021 - 05/2012
4	Interleukin-6 (Interleukin 6)IBA 01/2021 - 06/2011
4	Peptides (Polypeptides)IBA 06/2018 - 08/2011
4	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 12/2009
4	MicroRNAs (MicroRNA)IBA 01/2017 - 04/2015
4	Small Interfering RNA (siRNA)IBA 04/2015 - 02/2013
3	AcidsIBA 08/2023 - 01/2012
3	Gonadal Steroid Hormones (Sex Hormones)IBA 08/2022 - 01/2020
3	Neurotransmitter Agents (Neurotransmitter)IBA 08/2022 - 04/2015
3	Dopamine (Intropin)FDA LinkGeneric 08/2022 - 11/2003
3	C-Reactive ProteinIBA 11/2021 - 01/2015
3	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 04/2016
3	CannabinoidsIBA 01/2021 - 10/2012
3	Whey ProteinsIBA 01/2021 - 12/2013
3	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2012
3	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021 - 06/2006
3	Glucose (Dextrose)FDA LinkGeneric 03/2020 - 06/2012
3	Protein Isoforms (Isoforms)IBA 01/2020 - 10/2014
3	Hormones (Hormone)IBA 06/2018 - 01/2010
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2016 - 05/2010
3	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2016 - 06/2006
3	5-HT2C Serotonin ReceptorIBA 07/2015 - 06/2007
3	metabotropic glutamate receptor 7IBA 06/2006 - 06/2003
2	LipopolysaccharidesIBA 08/2023 - 08/2022
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 12/2022 - 05/2020

Therapy/Procedure

29	Therapeutics 11/2023 - 01/2010
5	Cesarean Section (Caesarean Section) 01/2022 - 05/2015
4	Drug Therapy (Chemotherapy) 01/2022 - 11/2005
4	Traction 10/2019 - 04/2008
3	Fecal Microbiota Transplantation 11/2021 - 11/2016
3	RNAi Therapeutics 10/2015 - 02/2013
2	Ketogenic Diet 01/2023 - 01/2022
2	Transplantation 01/2023 - 01/2022